Hormones & Fertility
Enclomiphene Citrate
Androxal · trans-clomiphene · the "good half" of Clomid
What it is
Enclomiphene is one of the two stereoisomers in Clomid (clomiphene citrate). The traditional Clomid drug is a 50/50 mix of enclomiphene (the "good" isomer that boosts testosterone) and zuclomiphene (the "bad" isomer that causes mood, vision, and emotional side effects). Enclomiphene-only purified products give you Clomid's benefits without the side effects.
How it works
A SERM (selective estrogen receptor modulator) that blocks estrogen at the pituitary. The pituitary normally senses high estrogen as feedback to slow down LH and FSH production. Enclomiphene tricks it into thinking estrogen is low, causing more LH/FSH release, which drives more testosterone and supports fertility.
Benefits
- Nearly doubles natural testosterone
- Maintains or improves fertility (sperm count and motility)
- Oral — no injections required
- No vision/mood side effects of Clomid
- Cleaner alternative to TRT for younger men with secondary hypogonadism
Timeline
- Week 1–2
- LH/FSH and testosterone start rising.
- Week 4
- Testosterone often nearly doubled from baseline.
- Month 2–3
- Sperm count improvements visible.
Dosing & titration
Standard dose12.5–25 mg orally daily
Cycle length3–6 months on, optional break
TimingAM with food
When to titrate upIf testosterone hasn't risen meaningfully at 12.5 mg after 4 weeks, increase to 25 mg. Most users do well at 12.5–25 mg/day.
Side effects & risks
- Generally well tolerated
- Possible mood changes (less than Clomid)
- Estrogen rise (often desired alongside testosterone)
- Headache (occasional)
- Hot flashes (rare)
Best for younger men with secondary hypogonadism. Get baseline T, LH, FSH, estradiol. Re-test at 4–6 weeks.
Typical price
$30–$100/moFrom a 503A compounding pharmacy.
Studies
- Wiehle RD et al. Enclomiphene citrate stimulates testosterone production while preventing oligospermia — Established efficacy and fertility preservation. PubMedFertility & Sterility, 2014
- Search PubMed for enclomiphene — PubMed searchLive PubMed search
Educational reference only. Not medical advice.