Cognitive / Nootropic

Dihexa

PNB-0408 · N-hexanoic-Tyr-Ile-(6) aminohexanoic amide

experimentalcutting-edgeoral or sublingual

What it is

Dihexa is a small molecule developed at Washington State University as an angiotensin IV analog. Reportedly ~7–10 million times more potent than BDNF at promoting synaptogenesis (formation of new synapses between neurons). One of the strongest known cognitive enhancers in animal models.

How it works

Activates the hepatocyte growth factor (HGF) receptor c-Met, triggering intracellular signaling that builds new synaptic connections. Crosses the blood-brain barrier readily. Effects are durable — new synapses persist after dosing stops.

Benefits

Massive synaptogenesis — new neural connections
Memory and learning enhancement
Possible reversal of cognitive decline (Alzheimer's research)
Long-lasting effects (synapses persist)
Crosses blood-brain barrier orally

Timeline

Day 1–3: Subtle clarity changes.
Week 1–2: Memory and learning improvements.
Week 4–6: Cumulative cognitive benefits.
After: Effects persist due to durable synaptic changes.

Dosing & titration

Standard dose8–25 mg orally or sublingually daily

Cycle length2–4 weeks; long cycles uncommon

TimingAM with food

When to titrate upLimited human dose-response data. Start at low end.

Side effects & risks

Limited human safety data
Possible cancer-risk concerns due to growth-factor-like activity
Some users report headaches, anxiety, restlessness
Theoretical risk: c-Met activation is cancer-relevant

Cancer caveat: c-Met activation is implicated in tumor growth. Long-term safety data is essentially nonexistent in humans. Use with caution and short cycles only.

Typical price

$80–$160/moCapsules from research suppliers. Quality varies wildly.

Studies

McCoy AT et al. Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents — Foundational paper. PubMedJournal of Pharmacology and Experimental Therapeutics, 2013
Search PubMed for dihexa — PubMed searchLive PubMed search

Educational reference only. Not medical advice.